Oscar and Lucinda.
Which is both the title and the characters. It's odd, but beautiful.
Science of Sleep, Stephane and Stephanie. Awkward, odd, and you're not quite sure what just happened, but adorable.
though it's tv, Oz and Willow will always be my favourite couple..from Buffy. Also Zoe and Wash from Firefly while we're at it. You go Joss.